The role of fatty acid/triglyceride cycling in maintenance of mitochondrial integrity and cellular health, and its contribution to thermogenesis in adipose tissues (P17)

• Subject Area: Cell Biology ; Anatomy and Physiology ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Brown adipocytes lacking uncoupling protein 1 (UCP1) recruit a futile fatty acid/triglyceride (FA/TG) cycle for thermogenesis. Futile FA/TG cycling, may control intracellular free fatty acid levels, and thereby avert lipotoxicity. We aim to elucidate the role of the key enzyme DGAT1 (Diacylglycerol-O-Acyltransferase 1) and the peri-lipid droplet mitochondria in FA/TG cycling, and study the impact of FA/TG cycling on the cellular lipidome, organelle and cellular crosstalk, and whole body energy expenditure.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Martin Klingenspor