Molecular role of the mitochondrial unfolded protein response in white and brown adipose tissue for whole body glucose homeostasis (P14)

• Subject Area: Cell Biology ; Endocrinology, Diabetology, Metabolism ; Nutritional Sciences
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Functional disturbances of adipocyte mitochondria can affect systemic glucose tolerance via adipocyte-intrinsic mechanisms like impaired glucose uptake and altered differentiation processes (e.g. browning of WAT) as well as via metabolic- or endocrine-derived signals to remote tissues. Using new conditional knockout mouse models and high-fat diet feeding in combination with interventional studies employing pharmacological relevant substances, this project aims to unravel the role of MT-UPR signalling for the maintenance of adipocyte functions in WAT and BAT and its contribution to sustain whole body glucose homeostasis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Martin Klingenspor; Dr. Eva Rath