The role of ChREBP-dependent de novo lipogenesis in metabolic and thermogenic activities of brown and white adipose tissue (P13)

• Subject Area: Cell Biology ; Anatomy and Physiology ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Brown and beige adipocytes exhibit high de novo lipogenesis (DNL), the synthesis of endogenous fatty acids. The reasons for high DNL capacity in thermogenic adipose tissues are unknown. We have found that carbohydrate response element-binding protein (ChREBP) controls DNL enzymes in brown adipocytes. In this project, we want to explore how ChREBP isoforms regulate DNL and other cellular functions in thermogenic adipose tissue. Furthermore, we aim to identify mechanisms linking DNL to adaptive thermogenesis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Dr. Ludger Scheja