Regulation and adaptation of G-protein coupled receptors/adenylyl cyclase/cAMP signaling networks in brown/beige AT (P10)

• Subject Area: Pharmacology ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

G-protein coupled receptor (GPCR) signaling pathways, coupling to adenyly cyclases (ACs) and cAMP signaling, constitute the central signaling pathway for activating lipolysis and energy expenditure in thermogenic adipocytes. In this project, we will study the function of GPCRs and ACs specifically expressed in brown and beige adipose tissue and their regulation depending on the activation status of thermogenic AT in vitro and in vivo. Thereby, we will unravel how GPCR/AC signaling adapts to physiological and pathological stimuli in the context of adaptive thermogenesis and systemic energy metabolism.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Alexander Pfeifer; Professorin Dr. Dagmar Wachten