Metabolic regulation through the aryl hydrocarbon receptor repressor (AhRR) via immune cell/adipocyte interactions (P08)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, regulated by the AhR Repressor (AhRR). We have discovered that myeloid cell-specific AhRR-deficient mice are protected from diet-induced obesity and feature signs of browning. In this project, we want to investigate the influence of the AhRR on the interaction of immune cells with brown/beige adipocytes to ultimately identify AhRR-dependent mediators regulating thermogenesis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professorin Dr. Irmgard Förster