Project Details
Projekt
EXC 306: Inflammation at Interfaces
Subject Area
Microbiology, Virology and Immunology
Term
from 2007 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 49701054
Inflammation at barrier organs (skin, lung, gut) is a central medical problem including many civilisation diseases such as asthma and chronic inflammatory bowel disease. The vision of the cluster of excellence is that barrier problems may be causally involved in many other systemic inflammatory (e.g. coronary heart disease) and malignant (e.g. colorectal carcinoma) disorders.
To improve the multidisciplinary study of barrier disorders, the cluster of excellence will restructure research at five faculties at the universities of Kiel and Lübeck and the Research Center Borstel, Leibniz-Center for Medicine and Biosciences. Twenty-nine principal investigators and 108 additional excellent scientists have established five content- and method-defined research areas by joining their individual research operations, which together will streamline the scientific processes of the investigation of diseases from genomic discovery to model-system based mechanistic understanding and its validation at the patient level. This leads to a new quality of multidisciplinary research translating a synergistic generation of knowledge around etiologically relevant molecule families into application in inflammatory barrier diseases and their treatment.
The research environment forms the basis of an innovative concept of interdepartmental postgraduate education (medicine/life sciences). The applicant institutions have committed to the inauguration of 21 new professorships and departments to complement and strengthen the research environment. The multidisciplinary structure of the cluster of excellence provides the scientific environment for twelve new independent junior research groups ensuring early independence and promoting gender-equality of young scientists. Finally, the establishment of a clinical "Comprehensive Center for Inflammation Medicine" (CCIM) ensures a permanent, multidisciplinary integration between different clinical sub-disciplines and basic research; in addition it facilitates the cooperation with industry.
To improve the multidisciplinary study of barrier disorders, the cluster of excellence will restructure research at five faculties at the universities of Kiel and Lübeck and the Research Center Borstel, Leibniz-Center for Medicine and Biosciences. Twenty-nine principal investigators and 108 additional excellent scientists have established five content- and method-defined research areas by joining their individual research operations, which together will streamline the scientific processes of the investigation of diseases from genomic discovery to model-system based mechanistic understanding and its validation at the patient level. This leads to a new quality of multidisciplinary research translating a synergistic generation of knowledge around etiologically relevant molecule families into application in inflammatory barrier diseases and their treatment.
The research environment forms the basis of an innovative concept of interdepartmental postgraduate education (medicine/life sciences). The applicant institutions have committed to the inauguration of 21 new professorships and departments to complement and strengthen the research environment. The multidisciplinary structure of the cluster of excellence provides the scientific environment for twelve new independent junior research groups ensuring early independence and promoting gender-equality of young scientists. Finally, the establishment of a clinical "Comprehensive Center for Inflammation Medicine" (CCIM) ensures a permanent, multidisciplinary integration between different clinical sub-disciplines and basic research; in addition it facilitates the cooperation with industry.
DFG Programme
Clusters of Excellence
Applicant Institution
Christian-Albrechts-Universität zu Kiel
Co-Applicant Institution
Universität zu Lübeck
Participating Institution
Forschungszentrum Borstel
Leibniz Lungenzentrum; Max-Planck-Institut für Evolutionsbiologie
Leibniz Lungenzentrum; Max-Planck-Institut für Evolutionsbiologie
Spokesperson
Professor Dr. Stefan Schreiber
Participating Researchers
Professor Dr. Thomas C. G. Bosch; Professor Dr. Stefan Ehlers; Professorin Dr. Jeanette Erdmann (†); Professor Dr. Rainer Ernst (†); Professor Dr. Andre Franke; Professor Dr. Wolfgang L. Gross; Professor Dr. Rolf Hilgenfeld; Professor Dr. Dietrich Kabelitz; Professor Dr. Jörg Köhl; Professor Dr. Rudolf Manz; Professorin Dr. Almut Nebel; Professor Dr. Stefan Niemann; Professor Dr. Klaus F. Rabe; Professor Dr. Gerald Rimbach; Professor Dr. Stefan Rose-John; Professor Philip Caspar Rosenstiel, Ph.D.; Professor Dr. Paul Saftig; Professor Dr. Ulrich E. Schaible; Professor Dr. Jens-Michael Schröder; Professor Dr. Stefan Schütze; Professor Dr. Reiner Siebert; Professor Dr. Diethard Tautz; Professor Dr. Stephan Weidinger; Professor Dr. Detlef Zillikens (†)
