Epigenetic clocks, blood-based biomarkers and functional parameters for the estimation of biological age (C06)

• Subject Area: Cell Biology ; General Genetics and Functional Genome Biology ; Epidemiology and Medical Biometry/Statistics ; Biogerontology and Geriatric Medicine
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

There is an unmet need to find an adequate model for biological age. In this project, we use the well characterized ActiFE cohort to develop a model for biological age based on blood-based biomarkers, relevant clinical and functional parameters, and targeted epigenetic clocks. The analysis will also integrate new concepts based on DNA methylation analysis. In a translational approach we will examine epigenetic clocks also in mice. Our joint research will investigate the interface between biological age, frailty, and epigenetic aging to provide a new construct for biological age assessment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Heads: Dhayana Dallmeier, Ph.D.; Professor Dr. Dietrich Rothenbacher; Professor Dr. Wolfgang Wagner