Modulation of the macrophage/adipocyte interface in age-related insulin resistance by the Glucocorticoid Receptor (C05)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Biophysics
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

The glucocorticoid receptor (GR) promotes insulin resistance (IR) in middle-aged mice through its action in adipocytes, but protects against insulin resistance through its expression in macrophages and in adipocytes of old mice. We now aim to decipher the dynamics of the cellular macrophage/adipocyte interface and its interplay with the molecular GR/cofactor interface by performing biochemical and single-molecule studies of GR-dependent signatures in primary cells of transgenic rodents and aged humans.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Heads: Professor Dr. Christof Gebhardt; Professor Dr. Jan Tuckermann