Mechanisms of aging and rejuvenation of human hematopoietic stem cells (B01)

• Subject Area: Biogerontology and Geriatric Medicine ; Hematology, Oncology ; Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

The project will investigate the age-related functional decline of hematopoiesis and dissect the role of Cdc42 in the rejuvenation of Human Hematopoietic Stem Cells (HSCs). It will additionally focus on, using single-cell sequencing and deep learning approaches, the transcriptional and mutational heterogeneity of HSCs upon aging. As an outlook, we aim to develop personalized anti-aging clinical interventions that will attenuate aging-driven immune remodeling and hematopoietic disorders.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Heads: Professor Dr. Hartmut Geiger; Professor Medhanie Mulaw, Ph.D.