Kinase cascades in neutrophils as therapeutic target in pemphigoid diseases (B04)

• Subject Area: Dermatology ; Clinical Immunology and Allergology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

In pemphigoid diseases (PDs), neutrophils are activated by IgG autoantibodies deposited at the dermal-epidermal junction. Intracellular signaling cascades induced by IgG binding to FcγRs ultimately lead to the release of effector molecules, such as proteases and ROS, resulting in skin blistering and erosions. Hence, these signaling cascades, mostly consisting of kinases, are promising therapeutic targets. B04 therefore aims to comprehensively characterize these kinase cascades and to examine the therapeutic potential of inhibitors of select kinases for PDs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• Applicant Institution: Universität zu Lübeck
• Project Heads: Privatdozentin Dr. Katja Bieber; Professorin Dr. Anja Lux