Skin-infiltrating T and B cells in the pathogenesis of pemphigoid diseases (A08)

• Subject Area: Immunology ; Dermatology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

Project A08 aims to understand how the T cell-driven local autoantibody production contributes to skin inflammation. We have preliminary data from both pemphigoid disease patients and a mouse model of pemphigoid diseases that so-called peripheral T helper cells interact directly in the skin with inflammatory T-bet+ B cells. Using multi-parametric flow cytometry, laser-scanning microscopy, and single cell sequencing, we plan to dissect these interactions on a molecular level. We furthermore aim to analyze how T and B cells interact with neutrophils and other inflammatory cells in skin infiltrates.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• International Connection: United Arab Emirates
• Applicant Institution: Universität zu Lübeck
• Project Heads: Professor Dr. Andreas Hutloff; Professor Dr. Saleh M. Ibrahim