Imaging structure/function relations in HFpEF - from pathomechanism to artificial-intelligence based classification (B06)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

Cardiovascular MRI (CMR) is the gold standard for quantitative assessment of anatomy, function, and hemodynamics, as well as myocardial tissue changes such as fibrosis, inflammatory response, and fatty infiltration. B06 investigates the hypothesis that innovative CMR imaging combined with artificial intelligence will enable improved differentiation of prevalent HFpEF pathologies. To this end, a CMR-based Heart Failure Remodeling Index (CMR-HRI) will be developed and pathomechanisms of HFpEF phenotypes will be analyzed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr.-Ing. Anja Hennemuth; Professor Dr. Sebastian Kelle