Molecular plasticity of HFpEF (B05)

• Subject Area: Cardiology, Angiology ; Biochemistry ; Bioinformatics and Theoretical Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

HFpEF is a heterogenous clinical syndrome with incomplete mechanistic understanding. To improve our understanding of the molecular disease mechanisms, we will perform in-depth proteomic analyses of well phenotyped HFpEF patients and our central HFD+L-NAME mouse model both under resting conditions as well as under disease mitigating exercise conditions. We will also explore disease-specific alterations in proteostasis by studying protein ubiquitination in heart and skeletal muscle tissues in a sex-specific manner. The acquired molecular signatures will be bioinformatically connected to changes in key clinical and pathophysiological readouts to improve patient stratification, identify new biomarkers and potential new therapeutic targets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Frank Edelmann, since 11/2022; Dr. Philipp Mertins; Professor Dr. Burkert Pieske, until 11/2022