Bariatric surgery as a key model to unravel microbiome-based treatment targets modulating adipose tissue thermogenesis (P01)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Bariatric surgery significantly alters the gut microbiota composition and function, which associate with an improved metabolic profile and enhanced brown adipose tissue activity. Based on own experimental data, suggesting a causal role of the altered inter-organ crosstalk between gut microbiota and thermogenic adipose tissue in post-surgery weight loss and metabolic improvements, this project aims to determine the metabolic network correlating with thermogenic plasticity and identify active microbiota signaling candidates which may qualify to reactivate thermogenesis in human obesity.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professorin Dr. Wiebke Kristin Fenske