GRK 2873:  Tools and Drugs of the Future - Innovative Methods and New Modalities in Medicinal Chemistry

• Subject Area: Medicine
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 494832089

Medicinal Chemistry is a highly interdisciplinary field of research that focuses on the discovery, characterization and development of bioactive tool compounds and drugs. In recent years, the target landscape as well as the types of drug molecules (“drug modalities”) and the methods employed in Medicinal Chemistry and drug research have significantly changed. In the planned RTG we therefore intend to educate and train a future generation of medicinal chemists that will be well prepared to master future challenges. Different strategies will be employed to discover tools and drugs for novel types of targets. The research program focuses on four core themes that are closely interconnected: (I) targeted protein degraders (PROTACs), (II) macrocyclic drugs, (III) biopolymers as tools and drugs, and (IV) drug conjugates. The research projects are supported by jointly used technology platforms: the proprietary Pharma-Zentrum Bonn compound library, the Center of Aptamer Research and Development CARD, a structural biology platform, and a platform of advanced instruments in medicinal chemistry. This RTG proposal has been composed by leading researchers from five different institutes of two faculties (Faculty of Mathematics and Natural Sciences and Faculty of Medicine), who have a history of previous successful collaborations. The diverse group of PIs comprises experienced as well as young aspiring researchers. The broad scientific backgrounds of the researchers and their interconnections will allow us to gain considerable synergies in covering a wide variety of new modalities, all of which have in common that they differ from classical drugs: their properties are beyond Lipinski’s rule of 5 (Ro5) resulting in similar problems that have to be solved. The RTG will allow close interactions to tackle the resulting scientific questions. The University of Bonn and its surroundings, including industry partners, provide an ideal environment not only for research in Medicinal Chemistry, but also for translational drug development. We have planned a 3- to 4-year qualification program for the doctoral researchers. It comprises a lecture series in advanced medicinal chemistry, workshops, a central doctoral colloquium, an international lecture series and an international career development program comprising courses in soft skills, science philosophy and ethics in science. We will closely collaborate with our privileged international partner institutions, the Universities of Copenhagen (Denmark), Dundee (Scotland) and Tohoku (Japan) with which we have agreed on a lab exchange program for the doctoral students. We will innovate in key areas of medicinal chemistry and educate and train a new generation of medicinal chemists and young scientists at the interface between medicinal chemistry and interconnected disciplines. Moreover, the research projects will contribute to drug research and development for the benefit of patients.

• DFG Programme: Research Training Groups
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Spokesperson: Professorin Dr. Christa E. Müller
• Participating Researchers: Professor Dr. Gerd Bendas; Dr. Max Crüsemann; Professor Dr. Michael Gütschow; Professor Dr. Finn Kristian Hansen; Professorin Dr. Evi Kostenis; Professor Dr. Günter Mayer; Professor Dr. Dirk Menche; Dr. Anna Müller; Professorin Dr. Tanja Schneider; Dr. Christian Steinebach; Professor Dr. Günther Weindl