Harnessing defective DNA repair for the treatment of mantle cell lymphoma (C02)

• Subject Area: Cell Biology ; Hematology, Oncology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452

B cell development is dependent on functional DNA repair and thus deficiencies within these pathways promote lymphomagenesis and are frequently found in high-risk B cell lymphomas. In this project, mantle cell lymphoma (MCL) will serve as a blueprint, as alterations in key DNA repair pathways are typically present in up to 50% of cases without being therapeutically exploited to date. We will perform functional and longitudinal profiling of genome instability in a high-risk relapse/refractory MCL cohort and mechanistically dissect the kinase-driven DNA repair pathways in order to identify and validate vulnerabilities of rewired DNA repair signaling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
• Applicant Institution: Universität zu Köln
• Project Head: Dr. Ron Jachimowicz