Project Details
Tumor heterogeneity and genomic instability in classical Hodgkin lymphoma (C01)
Subject Area
Immunology
Hematology, Oncology
Hematology, Oncology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452
Hodgkin lymphoma is a unique B cell lymphoma regarding the phenotypic heterogeneity of the Hodgkin and Reed-Sternberg (HRS) lymphoma cells, the extent of chromosomal abnormalities, and the occurrence of bi-/multinucleated lymphoma cells. We plan an in-depth analysis of the transcriptomic and epigenetic heterogeneity of single HRS cells, as well as of the genetic heterogeneity and instability of these cells. Furthermore, we plan to uncover the mechanisms causing the generation of bi-/multinuclear lymphoma cells. A comparative analysis of diffuse large B cell lymphomas will uncover common and distinct mechanisms of genetic instability and tumor heterogeneity in these lymphomas.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität zu Köln
Project Head
Professor Dr. Ralf Küppers