Role of apoptotic caspases in lymphomagenesis (A04)

• Subject Area: Hematology, Oncology ; Immunology ; Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452

Apoptosis resistance represents one of the keys giving rise to the pathogenesis of B-cell lymphoma. Caspases have been primarily considered as engines of apoptosis. However, accumulating evidence indicated that caspases are versatile molecular switches that control B-cell proliferation, inflammatory signaling, and differentiation. This project will provide in-depth molecular knowledge about the physiological roles of caspases in B-cell malignancies. The knowledge obtained will be exploited to better understand the pathogenesis of B-cell lymphoma and, in particular, will provide basis for the development of novel therapeutic strategies against B-cell malignancies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Hamid Kashkar