Bacterial effector-mediated interference with PGN-perception in plants (B07)

• Subject Area: Plant Biochemistry and Biophysics
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32152271

We are planning to elucidate mechanisms by which bacterial phytopathogens interfere with the recognition of PGN by the plant immune system. Part one aims at the identification of bacterial inhibitors for the Arabidopsis lysozyme LYS1. Moreover, we will address the question if specific structural features of the PGN of phytopathogenic bacteria (e.g. Pseudomonas syringae pv tomato, adapted to their host) differ from non-adapted bacteria (e.g. E. coli) to confer protection against LYS1 enzymatic activity. In part two of this project we envisage identifying bacterial components interfering with binding to and/or recognition of immunogenic PGN fragments via the PGN receptor proteins LYM1, LYM3 and CERK1.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 766: The Bacterial Cell Envelope: Structure, Function and Infection Interface
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Heads: Dr. Andrea A. Gust; Professor Dr. Thorsten Nürnberger, until 6/2015