Structure and evolution of protein fibers at the bacterial cell surface (B04)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32152271

We intend to perform a structural and functional analysis of mempromCC, a new protein family comprising of prokaryotic and mitochondrial membrane associated coiled coil proteins. We will perform a comprehensive bioinformatic analysis with regard to phylogeny, sequence conservation and domain structure. From the combination of this analysis with structural data and the results of binding and knock-out experiments, we expect information concerning the cellular function of these proteins. Based on these results, we intend to perform a comparative functional analysis of prokaryotic and eukaryotic homologs in yeast mitochondria.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 766: The Bacterial Cell Envelope: Structure, Function and Infection Interface
• Applicant Institution: Eberhard Karls Universität Tübingen
• Co-Applicant Institution: Max-Planck-Institut für Biologie
• Project Heads: Dr. Birte Hernandez Alvarez; Professor Dr. Andrei N. Lupas