GRK 1482:  Interface Functions of the Intestine between Luminal Factors and Host Signals

• Subject Area: Medicine ; Microbiology, Virology and Immunology
• Term: from 2008 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 48329094

• Final Report Year: 2018

Final Report Abstract

The GRK 1482 brings together a unique spectrum of experts from nutrition, biology, human physiology, food microbiology and the medical sciences for research on the gastrointestinal tract in health and disease states. Research of the last decade has brought to light that the intestine is a prime organ in control of mammalian energy and nutrient metabolism by its endocrine functions and in hosting a complex microbiota of commensal bacteria that contribute to inflammatory processes and immune functions. Lifestyle changes in the industrialized world, including a high caloric intake (over-nutrition), are associated with a sharp increase in the incidence of chronic inflammatory disorders of the gastrointestinal tract including Crohn’s disease and ulcerative colitis as well obesity-driven dysregulation of glucose and lipid metabolism. The GRK with its different projects addresses some of the important environmental and dietary factors that contribute on the background of genetic predispositions to disease development. The gastrointestinal tract acts as an important barrier and communication organ at the interface between the luminal environment, including nutritional and microbial factors, and the host. Signals derived from this interplay are transmitted through epithelial, immune, neuronal and hormonal networks and affect intestinal functions as well as peripheral tissues of the host. Inflammatory processes play a particular role in shaping these interactions towards a disease susceptible milieu that favors the development of chronic disorders including inflammatory bowel diseases (IBD) and obesity-driven metabolic dysregulation. Nutrition and gut luminal factors such as microbes are most likely the prime environmental factors that not only determine a healthy gut phenotype but also shape a disease-conditioning situation in the susceptible host. Although substantial progress has been made in identifying genetic variations associated with IBD, obesity and type-2 diabetes, striking evidence has been generated in both immune-mediated and metabolic disorders demonstrating that environmental triggers are the driving force for chronic disease development. Mechanisms that determine the transition from physiological functions in healthy subjects towards disease-relevant situations are critical to understand in the life-long exposure to nutritional factors and commensal microbes. Specifically, the number of bacterial cells constituting the intestinal microbiome roughly matches the cellularity of the human body (3.8 x 10^13). On the metagenomics level, this enormous microbial mass entails a striking degree of genetic variation that contributes to the complexity of systemic control mechanisms, and comes more and more into the focus of metabolic functions and disorders. There can be no doubt that the intestinal interface as a barrier and communication organ between microbes and its host plays a pivotal role in this interaction. Bacteria are crucial determinants in chronic inflammatory disorders and IBD serves as a paradigm to study the principles of microbe-host interactions in the gut. The potential for future development and innovation lies within the interaction of disease categories and the gut interface as therapeutic target.

Publications

• Development of a stable isotope dilution analysis for the quantification of the Bacillus cereus toxin cereulide in foods. J Agric Food Chem. 2010, 58: 1420-1428
  Bauer T, Stark T, Hofmann T, Ehling-Schulz M
  (See online at https://doi.org/10.1021/jf9033046)
• Die Bedeutung von Eisen bei chronisch entzündlichen Darmerkrankungen. In: Bauchredner. DCCV e.V.-Mitgliederjournal, Gerd Rieker Verlag, Nackartalfingen, 2010, Heft 1
  Werner T, Wagner SJ, Haller D
  
• Identification and characterization of a glucan-producing enzyme from Lactobacillus hilgardii TMW 1.828 involved in granule formation of water kefir. Food Microbiol. 2010;27(5):672-8
  Waldherr FW, Doll VM, Meissner D, Vogel RF
  (See online at https://doi.org/10.1016/j.fm.2010.03.013)
• Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide. Neurogastroenterol Motil. 2010, 22: 1224-e320
  Krueger D, Foerster M, Mueller K, Zeller F, Slotta-Huspenina J, Donovan J, Grundy D, Schemann M
  (See online at https://doi.org/10.1111/j.1365-2982.2010.01571.x)
• Activity of protease-activated receptors in the human submucous plexus. Gastroenterology. 2011;141: 2088-2097
  Mueller K, Michel K, Krueger D, Demir IE, Ceyhan GO, Zeller F, Kreis ME, Schemann M
  (See online at https://doi.org/10.1053/j.gastro.2011.08.034)
• Comparison of genotypic and phenotypic cluster analyses of virulence determinants and possible role of CRISPR elements towards their incidence in Enterococcus faecalis and Enterococcus faecium. Syst Appl Microbiol. 2011 Dec;34(8):553-60
  Lindenstrauss AG, Pavlovic M, Bringmann A, Behr J, Ehrmann MA, Vogel RF
  (See online at https://doi.org/10.1016/j.syapm.2011.05.002)
• Depletion of luminal iron alters the gut microbiota and prevents Crohn's diseaselike ileitis. Gut. 2011 Mar;60(3):325-33
  Werner T, Wagner SJ, Martínez I, Walter J, Chang JS, Clavel T, Kisling S, Schuemann K, Haller D
  (See online at https://dx.doi.org/10.1136/gut.2010.216929)
• Eisen. In Praxishandbuch Functional Food. Erbersdobler HF, Mayer AH, Hrgb, Behr’s Verlag, 2011:1-39
  Schümann K, Becker C, Wagner SJ, Windisch W
  
• Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation. Gastroenterology. 2011;141(3):959-71
  Steck N, Hoffmann M, Sava IG, Kim SC, Hahne H, Tonkonogy SL, Mair K, Krueger D, Pruteanu M, Shanahan F, Vogelmann R, Schemann M, Kuster B, Sartor RB, Haller D
  (See online at https://doi.org/10.1053/j.gastro.2011.05.035)
• Fast calcium and voltage sensitive dye imaging in enteric neurons reveal calcium peaks associated with single action potential discharge. J Physiol. 2011, 589: 5941-7
  Michel M, Michaelis M, Mazzuoli G, Mueller K, Vanden Berghe P, Schemann M
  (See online at https://doi.org/10.1113/jphysiol.2011.219550)
• GC-Based Analysis of Plant Stanyl Fatty Acid Esters in Enriched Foods. J. Agric. Food Chem. 2011, 59: 5204-5214
  Barnsteiner A, Lubinus T, di Gianvito A, Schmid W, Engel KH
  (See online at https://doi.org/10.1021/jf104930z)
• Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice. The Journal of pharmacology and experimental therapeutics. J Pharmacol Exp Ther. 2011 Dec;339(3):790-8
  Haub S, Ritze Y, Ladel I, Saum K, Hubert A, Spruss A, Trautwein C, Bischoff SC
  (See online at https://doi.org/10.1124/jpet.111.181834)
• Bacterial proteases in IBD and IBS. Gut. 2012 Nov;61(11):1610-8
  Steck N, Mueller K, Schemann M, Haller D. and Haller D
  (See online at https://dx.doi.org/10.1136/gutjnl-2011-300775)
• Bacterial proteases in IBD and IBS. Gut. 2012 Nov;61(11):1610-8
  Steck N, Mueller K, Schemann M, Haller D
  (See online at https://dx.doi.org/10.1136/gutjnl-2011-300775)
• CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Gastroenterology. 2012;142(2):335-45
  Heiseke AF, Faul AC, Lehr HA, Förster I, Schmid RM, Krug AB, Reindl W
  (See online at https://doi.org/10.1053/j.gastro.2011.10.027)
• CodY orchestrates the expression of virulence determinants in emetic Bacillus cereus by impacting key regulatory circuits. Mol Microbiol. 2012;85(1):67-88
  Frenzel E, Doll V, Pauthner M, Lücking G, Scherer S, Ehling-Schulz M
  (See online at https://doi.org/10.1111/j.1365-2958.2012.08090.x)
• Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition. Br J Nutr. 2012 Aug 6:1-10
  Desmarchelier C, Ludwig T, Scheundel R, Rink N, Bader BL, Klingenspor M, Daniel H
  (See online at https://doi.org/10.1017/S0007114512003340)
• Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn’s disease-like ileitis. J Immunol. 2012 Aug 1;189(3):1510-20
  Chang JS, Ocvirk S, Berger E, Kisling S, Binder U, Skerra A, Lee AS, Haller D
  (See online at https://doi.org/10.4049/jimmunol.1200166)
• Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines. Cell Host Microbe. 2012,11(4):387-96
  von Schillde MA, Hörmannsperger G, Weiher M, Alpert CA, Hahne H, Bäuerl C, van Huynegem K, Steidler L, Hrncir T, Pérez-Martínez G, Küster B, Haller D
  (See online at https://doi.org/10.1016/j.chom.2012.02.006)
• Multi-Spezies- und Designer-Probiotika - Probiotika: Quo Vadis? Pharm. Unserer Zeit 2/2012(41);149-153
  von Schillde MA, Haller D
  (See online at https://doi.org/10.1002/pauz.201100464)
• Multi-Spezies- und Designer-Probiotika - Probiotika: Quo Vadis? Pharm. Unserer Zeit 2/2012(41);149-153
  von Schillde MA, Haller D
  (See online at https://doi.org/10.1002/pauz.201100464)
• Resistance to diet-induced obesity conferred by dietary bile acid supplementation in mice is strain specific. Exp Clin Endocrinol Diabetes 2012; 120 - A14
  Hüttinger K, Fromme T, Fiamoncini J, Daniel H, Klingenspor M
  (See online at https://doi.org/10.1055/s-0032-1330808)
• Structural studies of human insulin cocrystallized with phenol or resorcinol via powder diffraction. Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1632-41
  Karavassili F, Giannopoulou AE, Kotsiliti E, Knight L, Norrman M, Schluckebier G, Drube L, Fitch AN, Wright JP, Margiolaki I
  (See online at https://doi.org/10.1107/S0907444912039339)
• Tissue-specific differentiation of a circulating CCR9- pDC- like common dendritic cell precursor. Blood. 2012 Jun 21;119(25):6063-71
  Schlitzer A, Heiseke AF, Einwächter H, Reindl W, Schiemann M, Manta CP, See P, Niess JH, Suter T, Ginhoux F, Krug AB
  (See online at https://doi.org/10.1182/blood-2012-03-418400)
• Concerted action of sphingomyelinase and nonhemolytic enterotoxin in pathogenic Bacillus cereus. PLoS One. 2013; 8(4):e61404
  Doll VM, Ehling-Schulz M, Vogelmann R
  (See online at https://doi.org/10.1371/journal.pone.0061404)
• Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine. Neurogastroenterol Motil. 2013 Aug;25(8):e530-9
  Krueger D, Michel K, Allam S, Weiser T, Demir IE, Ceyhan GO, Zeller F, Schemann M
  (See online at https://doi.org/10.1111/nmo.12156)
• Fate of dietary phytosteryl/-stanyl esters: analysis of individual intact esters in human feces. Eur J Nutr 2013;52:997-1013
  Lubinus T, Barnsteiner A, Skurk T, Hauner H, Engel KH
  (See online at https://doi.org/10.1007/s00394-012-0407-4)
• Identification of fitness determinants in Enterococcus faecalis by differential proteomics. Arch Microbiol. 2013 Feb;195(2):121-30
  Lindenstrauss AG, Behr J, Ehrmann MA, Haller D, Vogel RF
  (See online at https://doi.org/10.1007/s00203-012-0857-3)
• IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity. 2013 May 23;38(5):970-83
  Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffel G, Malleret B, Heiseke A, Chew S, Jardine L, Purvis HA, Hilkens CM, Tam J, Poidinger M, Stanley ER, Krug AB, Renia L, Sivasankar B, Ng LG, Collin M, Ricciardi-Castagnoli P, Honda K, Haniffa M, Ginhoux F
  (See online at https://doi.org/10.1016/j.immuni.2013.04.011)
• Lactocepin as a protective microbial structure in the context of IBD. Gut Microbes 2013;1;4(2):152-7
  Hörmannsperger G, von Schillde MA, Haller D
  (See online at https://doi.org/10.4161/gmic.23444)
• Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab 2013;304:E1140-56
  Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL
  (See online at https://doi.org/10.1152/ajpendo.00171.2012)
• Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1140-56
  Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL
  (See online at https://doi.org/10.1152/ajpendo.00171.2012)
• Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/-absorption that protects them from diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2013 May 15;304(10):G897-907
  Kolodziejczak D, Spanier B, Pais R, Kraiczy J, Stelzl T, Gedrich K, Scherling C, Zietek T, Daniel H
  (See online at https://doi.org/10.1053/j.gastro.2011.05.035)
• Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/-absorption that protects them from diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2013;304(10):G897-907
  Kolodziejczak D, Spanier B, Pais R, Kraiczy J, Stelzl T, Gedrich K, Scherling C, Zietek T, Daniel H
  (See online at https://doi.org/10.1152/ajpgi.00160.2012)
• Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/malabsorption that protects them from diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2013 May 15;304(10):G897-907
  Kolodziejczak D, Spanier B, Pais R, Kraiczy J, Stelzl T, Gedrich K, Scherling C, Zietek T, Daniel H
  (See online at https://doi.org/10.1152/ajpgi.00160.2012)
• Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 2013 Dec;56(12):2688-96
  Diakogiannaki E, Pais R, Tolhurst G, Parker HE, Horscroft J, Rauscher B, Zietek T, Daniel H, Gribble FM, Reimann F
  (See online at https://doi.org/10.1007/s00125-013-3037-3)
• Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice. J Physiol 2013;591:5125- 39
  Reichardt F, Baudry C, Gruber L, Mazzuoli G, Moriez R, Scherling C, Kollmann P, Daniel H, Kisling S, Haller D, Neunlist M, Schemann M
  (See online at https://doi.org/10.1113/jphysiol.2013.262733)
• Semisynthetic diet ameliorates Crohn's disease-like ileitis in TNFΔARE/WT mice through antigen-independent mechanisms of gluten. Inflamm Bowel Dis. 2013 May;19(6):1285-94
  Wagner SJ, Schmidt A, Effenberger MJ, Gruber L, Danier J, Haller D
  (See online at https://doi.org/10.1097/MIB.0b013e318281f573)
• Semisynthetic diet ameliorates Crohn's disease-like ileitis in TNFΔARE/WT mice through antigen-independent mechanisms of gluten. Inflamm Bowel Dis. 2013 May;19(6):1285-94
  Wagner SJ, Schmidt A, Effenberger MJ, Gruber L, Danier J, Haller D
  (See online at https://doi.org/10.1097/MIB.0b013e318281f573)
• The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption. Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G66-73
  Wuensch T, Schulz S, Ullrich S, Lill N, Stelzl T, Rubio-Aliaga I, Loh G, Chamaillard M, Haller D, Daniel H
  (See online at https://doi.org/10.1152/ajpgi.00491.2012)
• The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption. Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G66-73
  Wuensch T, Schulz S, Ullrich S, Lill N, Stelzl T, Rubio-Aliaga I, Loh G, Chamaillard M, Haller D, Daniel H
  (See online at https://doi.org/10.1152/ajpgi.00491.2012)
• Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh--an ethnobotanical survey. J Ethnobiol Ethnomed. 2013 Jun 24;9:43
  Ocvirk S, Kistler M, Khan S, Talukder SH, Hauner H
  (See online at https://doi.org/10.1186/1746-4269-9-43)
• Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet. 2013 Oct;45(10):1216-20
  Witt H, Beer S, Rosendahl J, Chen J, Chandak GR, Masamune A, Bence M, Szmola R, Oracz G, Macek M, Bhatia E, Steigenberger S, Lasher D, Bühler F, Delaporte C, Tebbing J, Ludwig M, Pilsak C, Saum K, Bugert P, Masson E, Paliwal S, Bhaskar S, Sobczynska-Tomaszewska A, Bak D, Balascak I, Choudhuri G, Nageshwar Reddy D, Rao GV, Thomas V, Kume K, Nakano E, Kakuta Y, Shimosegawa T, Durko L, Szabó A, Schnúr A, Hegyi P, Rakonczay Z, Pfützer R, Schneider A, Groneberg DA, Braun M, Schmidt H, Witt U, Friess H, Algül H, Landt O, Schuelke M, Krüger R, Wiedenmann B, Schmidt F, Zimmer K, Kovacs P, Stumvoll M, Blüher M, Müller T, Janecke A, Teich N, Grützmann R, Schulz H, Mössner J, Keim V, Löhr M, Férec C, Sahin-Tóth M
  (See online at https://doi.org/10.1038/ng.2730)
• Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet. 2013 Oct;45(10):1216-20
  Witt H, Beer S, Rosendahl J, Chen JM, Chandak GR, Masamune A, Bence M, Szmola R, Oracz G, Macek M Jr, Bhatia E, Steigenberger S, Lasher D, Bühler F, Delaporte C, Tebbing J, Ludwig M, Pilsak C, Saum K, Bugert P, Masson E, Paliwal S, Bhaskar S, Sobczynska- Tomaszewska A, Bak D, Balascak I, Choudhuri G, Nageshwar Reddy D, Rao GV, Thomas V, Kume K, Nakano E, Kakuta Y, Shimosegawa T, Durko L, Szabó A, Schnúr A, Hegyi P, Rakonczay Z Jr, Pfützer R, Schneider A, Groneberg DA, Braun M, Schmidt H, Witt U, Friess H, Algül H, Landt O, Schuelke M, Krüger R, Wiedenmann B, Schmidt F, Zimmer KP, Kovacs P, Stumvoll M, Blüher M, Müller T, Janecke A, Teich N, Grützmann R, Schulz HU, Mössner J, Keim V, Löhr M, Férec C, Sahin-Tóth M
  (See online at https://doi.org/10.1038/ng.2730)
• Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation. Inflamm Bowel Dis. 2014 Apr;20(4):671- 84
  Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, Goebel U, Sartor RB, Prager M, Büning C, Bugert P, Witt H, Haller D, Daniel H
  (See online at https://doi.org/10.1097/01.MIB.0000443336.71488.08)
• From food to cell: nutrient exploitation strategies of enteropathogens. Microbiology 2014;160:1020-39
  Staib L, Fuchs TM
  (See online at https://doi.org/10.1099/mic.0.078105-0)
• Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Mol Metab 2014;3:565-80
  Dahlhoff C, Worsch S, Sailer M, Hummel BA, Fiamoncini J, Uebel K, Obeid R, Scherling C, Geisel J, Bader BL, Daniel H
  (See online at https://doi.org/10.1016/j.molmet.2014.04.010)
• RANTES (CCL5) reduces glucosedependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2014;307(3):G330-7
  Pai^s R, Zietek T, Hauner H, Daniel H, Skurk T
  (See online at https://doi.org/10.1152/ajpgi.00329.2013)
• Reducing the metagenomic sequence space for analysis of the gut microbiota by taxon-specific cell enrichment. DGHM & VAAM annual conference 05.-08.10.2014
  Bruder LM, Ludwig W, Liebl W
  
• Sensitivity testing in irritable bowel syndrome with rectal capsaicin stimulations: role of TRPV1 upregulation and sensitization in visceral hypersensitivity? Am J Gastroenterol 2014;109:99-109
  van Wanrooij SJ, Wouters MM, Van Oudenhove L, Vanbrabant W, Mondelaers S, Kollmann P, Kreutz F, Schemann M, Boeckxstaens GE
  (See online at https://doi.org/10.1038/ajg.2013.371)
• Temperature- and nitrogen source-dependent regulation of GlnR target genes in Listeria monocytogenes. FEMS Microbiol Lett. 2014 (2):131-41
  Kaspar D, Auer F, Schardt J, Schindele F, Ospina A, Held C, Ehrenreich A, Scherer S, Müller-Herbst S
  (See online at https://doi.org/10.1111/1574-6968.12458)
• Transcriptome analysis of Enterococcus faecalis toward its adaption to surviving in the mouse intestinal tract. Arch Microbiol. 2014 Jun;196(6):423-33
  Lindenstrauss AG, Ehrmann MA, Behr J, Landstorfer R, Haller D, Sartor RB, Vogel RF
  (See online at https://doi.org/10.1007/s00203-014-0982-2)
• Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids. PLoS One. 2014 Jul 10;9(7):e102063
  Szabó A, Salameh MA, Ludwig M, Radisky ES, Sahin-Tóth M
  (See online at https://doi.org/10.1371/journal.pone.0102063)
• Dietary iron depletion at weaning imprints low microbiome diversity and this is not recovered with oral Nano Fe(III). Microbiologyopen. 2015 Feb;4(1):12-27
  Pereira DI, Aslam MF, Frazer DM, Schmidt A, Walton GE, McCartney AL, Gibson GR, Anderson GJ, Powell JJ
  (See online at https://doi.org/10.1002/mbo3.213)
• Extracts from peppermint leaves, lemon balm leaves and in particular angelica roots mimic the pro-secretory action of the herbal preparation STW 5 in the human intestine. Phytomedicine. 2015 Nov 15;22(12):1063-70
  Allam S, Krueger D, Demir IE, Ceyhan G, Zeller F, Schemann M
  (See online at https://doi.org/10.1016/j.phymed.2015.08.008)
• IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut- Homing Capacity. J Immunol 2015;195:5787-94
  Heiseke AF, Jeuk BH, Markota A, Straub T, Lehr HA, Reindl W, Krug AB
  (See online at https://doi.org/10.4049/jimmunol.1501874)
• IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut- Homing Capacity. J Immunol 2015;195:5787-94
  Heiseke AF, Jeuk BH, Markota A, Straub T, Lehr HA, Reindl W, Krug AB
  (See online at https://doi.org/10.4049/jimmunol.1501874)
• Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology 2015. 156(3):923-33
  Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M
  (See online at https://doi.org/10.1210/en.2014-1689)
• Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids. Mol Nutr Food Res 2015;59:1573-83
  Fiamoncini J, Lima TM, Hirabara SM, Ecker J, Gorjao R, Romanatto T, A EL, Worsch S, Laumen H, Bader B, Daniel H, Curi R
  (See online at https://doi.org/10.1002/mnfr.201400743)
• Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis. J Biol Chem. 2015 Jul 10;290(28):17282-92
  Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M
  (See online at https://doi.org/10.1074/jbc.M114.618439)
• Regulation of fucose and 1,2-propanediol utilization by Salmonella enterica serovar Typhimurium. Front Microbiol 2015;6:1116
  Staib L, Fuchs TM
  (See online at https://doi.org/10.3389/fmicb.2015.01116)
• Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels. PLoS Pathog 2015;11:e1004911
  Ocvirk S, Sava IG, Lengfelder I, Lagkouvardos I, Steck N, Roh JH, Tchaptchet S, Bao Y, Hansen JJ, Huebner J, Carroll IM, Murray BE, Sartor RB, Haller D
  (See online at https://doi.org/10.1371/journal.ppat.1004911)
• Surface-associated lipoproteins link Enterococcus faecalis virulence to colitogenic activity in IL-10-deficient mice independent of their expression levels. PLoS Pathog. 2015 Jun 12;11(6):e1004911
  Ocvirk S, Sava IG, Lengfelder I, Lagkouvardos I, Steck N, Roh JH, Tchaptchet S, Bao Y, Hansen JJ, Huebner J, Carroll IM, Murray BE, Sartor RB, Haller D
  (See online at https://doi.org/10.1371/journal.ppat.1004911)
• Surface-associated lipoproteins link Enterococcus faecalis virulence to colitogenic activity in IL-10-deficient mice independent of their expression levels. PLoS Pathog. 2015 Jun 12;11(6):e1004911
  Ocvirk S, Sava IG, Lengfelder I, Lagkouvardos I, Steck N, Roh JH, Tchaptchet S, Bao Y, Hansen JJ, Huebner J, Carroll IM, Murray BE, Sartor RB, Haller D
  (See online at https://doi.org/10.1371/journal.ppat.1004911)
• Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G688-94
  Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H
  (See online at https://doi.org/10.1152/ajpgi.00241.2015)
• Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G688-94
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