The protective effects of physical activity on the cardiovascular system: role of NADPH oxidase 4 and the adrenals

• Applicants: Dr. Heike Brendel; Dr. Coy Brunssen
• Subject Area: Anatomy and Physiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 470814312

Frequent exercise can reduce mortality of cardiovascular disease. We and other groups have already been able to show that the major source for the formation of reactive oxygen species (ROS) in the vascular system, NADPH oxidase 4 (NOX4), has protective effects in the cardiovascular system. In addition, we demonstrated that Nox4-/- mice in voluntary running cages become less active and show reduced physical capacity compared with wild-type mice. Exercise also activates the endocrine system especially adrenal glands. Here, we were able to detect increased norepinephrine concentrations in urine of wild-type mice with voluntary running but not in the Nox4-/- mice. Our hypothesis is therefore that protective effects of physical exercise on the cardiovascular system are mediated through NOX4 and the adrenal glands.

• DFG Programme: Research Grants