Cell-specific activation of Wnt signaling in healing after myocardial infarction (A07*)

• Subject Area: Cell Biology ; Structural Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

Myocardial injury elicits a sterile immune response that impacts healing and subsequent ventricular function. We have recently identified a novel role for Wnt signaling in local activation of monocytes. In this subproject, we will determine the role of the Wnt signaling regulator FAM129B and the non-canonical Wnt signaling receptor ROR2, and their involvement in immune cell activation following myocardial infarction. It furthermore aims to elucidate the cell-type specific secretion of Wnt proteins and Wnt modulators and the spatio-temporal activation of Wnt signaling in cardiac cells that participate in the healing process after myocardial injury.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Florian Leuschner