New diagnostic methods to detect loosened hip arthroplasties (A03)

• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery ; Measurement Systems ; Primary Shaping and Reshaping Technology, Additive Manufacturing
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

The main objective of subproject A03 is to develop non-invasive methods to detect implant loosening in a differentiated manner and at a very early stage in order to avoid severe bone loss and thus improve conditions for the revision. The innovative concept provides a combination of two different methods: 1) Acoustic emission analysis will be established to characterise the fixation status of hip arthroplasties in conjunction with 2) rapid on-site detection of specific particles and biomolecules in body fluids using ion mobility spectrometry with electrospray ionisation, pyrolysis, and gas chromatographic pre-separation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Professor Dr.-Ing. Bernd-Arno Behrens; Dr. Eike Jakubowitz; Professor Dr.-Ing. Stefan Zimmermann