Prevention of late phase liver damage by targeted modulation of the liver’s immune response (C06*)

• Subject Area: Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

The liver plays a key role in the progression from uncomplicated infection to sepsis. Cross talk between parenchymal and immune cells is a key event in infection-driven liver dysfunction, and chemotactic factors including Cxcl-2 are responsible for the reorganisation of immune cells during the hyper-inflammatory response. We aim at promoting resolution of inflammation by targeting the cross talk using innovative, nanoparticle-mediated delivery of CRISPR / Cas9 machinery preventing massive immune cell recruitment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Michael Bauer; Professor Dr. Ulrich S. Schubert; Professorin Dr. Claudia Waskow