Targeting ferroptosis in adrenocortical carcinoma (ACC): from basic mechanisms to novel treatments (B20*)

• Subject Area: Animal Breeding, Animal Nutrition, Animal Husbandry
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Explore the function and therapeutic potential of FSP1 in ACC.(II) Elucidate selenium uptake and metabolism in adrenocortical cells in order to develop treatment strategies mimicking GPX4 inhibition.(III) Characterise the immunomodulatory effects of ferroptosis in ACC.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Dr. José Pedro Friedmann Angeli, since 7/2021; Professor Matthias Kroiß, Ph.D., since 7/2021; Dr. Isabel Weigand, since 7/2021