Regulation of prostanoid receptor signaling by orphan GPCRs of the GPRC5 family (A10*)

• Subject Area: Epidemiology and Medical Biometry/Statistics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 204083920

Aim of this project is to characterize the interaction between prostanoid receptors and members of the GPCR family GPRC5. In the first part of the project, we plan to investigate whether GPRC5B/C modulate prostacyclin receptor function in the context of cardiac fibrosis, pulmonary hypertension, or immune function. In the second part, we will determine whether GPRC5B/C also modulate other prostanoid receptors, and if so, what the functional consequences of this interaction are in the third.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1039: Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Nina Wettschureck