GRK 1121:  Genetic and Immunologic Determinants of Pathogen-Host-Interactions

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2005 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 462190

• Final Report Year: 2014

Final Report Abstract

The goal of the RTG1121 was to study pathogen-host interactions on the molecular level to provide a broad and modern education of doctoral students in the field of infection biology. The organisms of interest were viruses, bacteria and eukaryotic parasites in various hosts, comprising wellestablished model systems as well as so far understudied infections. The central scientific question was how pathogenic microbes infect their hosts, cause diseases and interact with the host’s immune response. To this aim, the projects of the RTG in both funding periods were arranged in two intertwined topics: - a cell biology oriented part, dealing with the pathogens’ pathogenicity factors allowing recognition and modification of the host cell, - an immunology-oriented part dealing with immune regulation and immune evasion in various infections. This concept proved very successful, as it allowed to bridge the traditional division between virology, bacteriology, parasitology and immunology, and provided a truly interdisciplinary framework for the doctoral students. Moreover, the integration of PIs from the fields of biology, veterinary medicine and medicine familiarized the students with a broad range of concepts. In addition, students got acquainted with hypothesis-driven research and data-driven approaches, such that they had the chance to develop integrative research projects. The RTG was composed of PIs from Humboldt-Universität zu Berlin, Charité-Universitätsmedizin Berlin and Freie Universität Berlin, as well as from the Max Planck Institute for Infection Biology, German Rheumatism Research Centre Berlin, Robert Koch Institute, Leibniz Institute for Zoo & Wildlife Research and the Institute for Bee Research Hohen Neuendorf. The participation of these diverse institutions expanded the scope of the doctoral researchers and allowed their access to the facilities and technical platforms of the PIs’ institutes. The RTG closely cooperated with the International Max Planck Research School for Infectious Diseases and Immunology and the RTG of CRC 650 “Cellular approaches to the suppression of unwanted immune reactions“. These programs had a similar thematic scope, which allowed to join forces regarding common recruitment of excellent international students, organization of a common infrastructure and development of common standards for thesis supervision and mentoring. The merger also increased the critical mass, which facilitated inputs into revisions of the universities’ promotion regulations and contributions to a master’s course of the Humboldt Universität. Overall, RTG 1121 provided 59 doctoral students (32 female/27 male) with a fellowship, a research training, consisting mostly of work on a research project (90%) and participation in / organization of seminars, courses, retreats and conferences (10%). The mean duration until submission of the thesis was 3.9 years.

Publications

• (2004) Proposal to reclassify Paenibacillus larvae subsp. pulvifaciens DSM 3615 (ATCC 49843) as Paenibacillus larvae subsp. larvae. Results of a comparative biochemical and genetic study; Veterinary Microbiology 104 31–42
  Jochen Kilwinski, Martin Peters, Ainura Ashiralieva, Elke Genersch
  
• (2005) A critical control element for interleukin-4 memory expression in T helper lymphocytes. J Biol Chem. 280(31):28177-85
  Tykocinski LO, Hajkova P, Chang HD, Stamm T, Soezeri O, Lohning M, Hu-Li J, Niesner U, Kreher S, Friedrich B, Pannetier C, Grutz G, Walter J, Paul WE, Radbruch A
  
• (2005) Cytogenetic characterization of a BCR-ABL transduced mouse Cell line. Cancer Genetics and Cytogenetics. Cancer Genet Cytogenet. Aug;161(1):51-6
  Cornelia Rudolph, Ahmed N. Hegazy, Nils von Neuhoff, Doris Steinemann, Evelin Schroeck, Renate Stripecke, Christoph Klein, Birgitte Schlegelberger
  
• (2005) Strain- and Genotype-Specific Differences in Virulence of Paenibacillus larvae subsp. larvae, a Bacterial Pathogen Causing American Foulbrood Disease in Honeybees; Applied and Environmental Microbiology 71 7551–7555
  Elke Genersch, Ainura Ashiralieva, and Ingemar Fries
  
• (2006) Generation and characterisation of a novel hematopoietic progenitor cell line with DC differentiation potential – a new method to amplify large numbers of DC for immunotherapy. Leukemia. 20(5):870-6
  Chozhavendan Rathinam, Martin Sauer, Arnab Ghosh, Cornelia Rudolph, Ahmed N. Hegazy, Brigitte Schlegelberger, Karl Welte, Christoph Klein
  
• (2006) HLA type-independent method to monitor Polyoma BK Virus specific CD4+ and CD8+ T cell immunity. American Journal of Transplant, 6: 625-631
  Hammer M.H, Brestrich G, Andree H, Engelmann E, Rosenberg C, Tillman H, Zwinger S, Babel N, Nickel P, Volk H-D, Reinke P
  
• (2006) Reclassification of Paenibacillus larvae subsp. pulvifaciens and Paenibacillus larvae subsp. larvae as Paenibacillus larvae without subspecies differentiation; International Journal of Systematic and Evolutionary Microbiology 56, 501-506
  Elke Genersch, Eva Forsgren, Jaana Pentikäinen, Ainura Ashiralieva, Sandra Rauch, Jochen Kilwinski, and Ingemar Fries
  
• (2006) Reclassification, genotypes and virulence of Paenibacillus larvae, the etiological agent of American foulbrood in honeybees – a review; Apidologie 37 411–420
  Ainura Ashiralieva, Elke Genersch
  
• (2006). Plasma cell differentiation in T-independent type 2immune responses is independent of CD11chigh dendritic cells. Eur. J. Immunol., 36, 2912-2919
  Hebel K., Griewank K, Inamine A, Chang HD, Mueller-Hilke B, Fillatreau S, Manz RA, Radbruch A, Jung S
  
• (2007) Avian pathogenic, uropathogenic, and newborn meningitis-causing Escherichia coli: how closely related are they? Int J Med Microbiol Jun;297(3):163-176
  Ewers C, Li G, Wilking H, Kiessling S, Alt K, Antão EM, Laturnus C, Diehl I, Glodde S, Homeier T, Böhnke U, Steinrück H, Philipp HC, Wieler LH
  
• (2007) Digital NFATc2 Activation per Cell Transforms Graded T Cell Receptor Activation into an All-or-None IL-2 Expression. PLoS ONE. , 2(9):e935
  Podtschaske M, Benary U, Zwinger S, Höfer T, Radbruch A, Baumgrass R
  
• (2007) Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 5(2):e38
  Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J
  
• (2007) Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3.Eur J Immunol.37(3):807-17
  Chang HD, Helbig C, Tykocinski L, Kreher S, Koeck J, Niesner U, Radbruch A
  
• (2007) Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nat Med. Nov;13(11):1316-23
  Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Philipp A Lang, Katja Fink, Stefan Freigang, Panco Georgiev, Lars Hangartner, Raphael Zellweger, Andreas Bergthaler, Ahmed N Hegazy, Bruno Eschli, Alexandre Theocharides, Lukas T Jeker, Doron Merkler, Bernhard Odermatt, Martin Hersberger, Hans Hengartner & Rolf M Zinkernagel
  
• (2007) Flip-flop of fluorescently labeled phospholipids in proteoliposomes reconstituted with Saccharomyces cerevisiae microsomal proteins. Eukaryotic Cell: 1625-1634
  Vehring S, Pakkiri L, Schröer A, Alder-Baerens N, Herrmann A, Menon AK, Pomorski T
  
• (2007) Generation of EBV-specific T Cells for Adoptive Immunotherapy: A Novel Protocol Using Formalin-fixed Stimulator Cells to Increase Biosafety. J Immunother, November/December;30(8):817-824
  Hammer MH, Brestrich G, Mittenzweig A, Roemhild A, Zwinger S, Subklewe M, Beier C, Kurtz A, Babel N, Volk HD, Reinke P
  
• (2007) IL-10 Is Excluded from the Functional Cytokine Memory of Human CD4+ Memory T Lymphocytes. J Immunol. 179(4):2389-96
  Dong J, Ivascu C, Chang HD, Wu P, Angeli R, Maggi L, Eckhardt F, Tykocinski L, Haefliger C, Mowes B, Sieper J, Radbruch A, Annunziato F, Thiel A
  
• (2007) The pro- and anti-inflammatory potential of interleukin-12. Ann N Y Acad Sci. 1109:40-6
  Chang HD, Radbruch A
  
• (2007) The pro- and antiinflammatory potential of IL-12: the dual role of Th1 cells. Expert Rev. Clin. Immunol., 3(5), 709-719
  Chang HD, Radbruch A
  
• Evalua- tion of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides. Eur J Pharmacol. 2007 Mar 22;559(2-3):138-49
  Librowski T, Kubacka M, Meusel M, Scolari S, Müller CE, Gütschow M
  
• “Negative vaccination” by specific CD4+ T cell tolerisation enhances virus-specific protective antibody responses. (2007) PLoS ONE. Nov 14;2(11):e1162
  Karl S. Lang, Ahmed N. Hegazy, Philipp A Lang, Bruno Eschli, Max Löhning, Hans Hengartner, Rolf M. Zinkernagel and Mike Recher
  
• (2008) A Hepatozoon species genetically distinct from H. canis infecting spotted hyena in the Serengeti Ecosystem, Tanzania. J Wildl Dis. 44(1):45-52
  East ML, Wibbelt G, Lieckfeldt D, Goller K, Wilhelm K, Schares G, Thierer D, Hofer H
  
• (2008) Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med. Jul;14(7):756-61
  Philipp A. Lang, Claudio Contaldo, Panco Georgiev, Ashraf M. El-Badry, Mike Recher, Michael Kurrer, Luisa Cervantes-Barragan, Burkhard Ludewig, Thomas Calzascia, Beatrice Bolinger, Doron Merkler, Bernhard Odermatt, Michael Bader, Rolf Graf, Pierre-Alain Clavien, Ahmed N. Hegazy, Max Löhning, Nicola L. Harris, Pamela S Ohashi, Hans Hengartner, Rolf M. Zinkernagel and Karl S. Lang
  
• (2008) Attempts to establish RNA interference in the parasitic nematode Heligmosomoides polygyrus. Mol Biochem Parasitol 161(1):21-31
  Lendner M, Doligalska M, Lucius R, Hartmann S
  
• (2008) Autoregulation of Th1-mediated inflammation by twist1. J Exp Med 205(8):1889-901
  Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A
  
• (2008) Characterization of a yjjQ mutant of avian pathogenic Escherichia coli (APEC). Microbiology;154, 1082-1093
  Li G, Ewers C, Laturnus C, Diehl I, Alt K, Dai J, Antao EM, Schnetz K and Wieler LH
  
• (2008) Ex vivo priming of CD4 T cells converts immunological tolerance into effective antitumor immunity in a murine model of acute lymphoblastic leukemia. Leukemia. 2008 Nov;22(11):2070-2079
  Ahmed N. Hegazy and Christoph Klein
  
• (2008) Innate- Like Effector Differentiation of Human Invariant NKT Cells Driven by IL-7. J Immunol. 180(7):4415-24
  de Lalla C, Festuccia N, Albrecht I, Chang HD, Andolfi G, Benninghoff U, Bombelli F, Borsellino G, Aiuti A, Radbruch A, Dellabona P, Casorati G
  
• (2008) Secondary structure and distribution of fusogenic LV- peptides in lipid membranes. Europ Biophys J 37:435-445
  Ollesch J., Poschner B., Nikolaus J., Hofmann M., Herrmann A., Gerwert K., Langosch D.
  
• (2008) The chicken as a natural model for extraintestinal infections caused by avian pathogenic Escherichia coli (APEC). Microb Pathog. 45(5-6):361-369
  Antão EM, Glodde S, Li G, Sharifi R, Homeier T, Laturnus C, Diehl I, Bethe A, Philipp HC, Preisinger R, Wieler LH, Ewers C
  
• (2008) The two-component system ScnRK of Streptococcus mutans affects hydrogen peroxide resistance and murine macrophage killing. Microbes and Infection. 10:293-301
  Chen, PM, HC Chen, CT Ho, CJ Jung, HT Lien, JY Chen, and JS Chia
  
• Long-lived virus-reactive CD4 memory T cells generated from purified cytokine-secreting T-helper-1 and T-helper-2 effectors. (2008) J Exp Med. Jan 21;205(1):53-61
  M. Löhning, A.N. Hegazy, D.D. Pinschewer, D. Busse, T. Höfer, A. Radbruch, R.M. Zinkernagel, and H. Hengartner
  
• (2009) Adhesive threads of extraintestinal pathogenic Escherichia coli. Gut Pathog. 1(1):22
  Antão EM, Wieler LH, Ewers C
  
• (2009) Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy. Am J Transplant 9(7):1679-1684
  Brestrich G, Zwinger S, Fischer A, Schmück M, Röhmhild A, Hammer MH, Kurtz A, Uharek L, Knosalla C, Lehmkuhl H, Volk HD, Reinke P
  
• (2009) Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy. Am J Transplant. 9(7):1679-84
  Brestrich G, Zwinger S, Fischer A, Schmück M, Röhmhild A, Hammer MH, Kurtz A, Uharek L, Knosalla C, Lehmkuhl H, Volk HD, Reinke P
  
• (2009) An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum. Eukaryot Cell 8(8):1134-1145
  Spork S, Hiss JA, Mandel K, Sommer M, Kooij TW, Chu T, Schneider G, Maier UG, Przyborski JM
  
• (2009) Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase. Cell Microbiol 11(12):1782-1801
  Uliczka F, Kornprobst T, Eitel J, Schneider D, Dersch P
  
• (2009) Establishment of infection despite increased Th2 responses and immunopathology after selective depletion of FoxP3+ cells. Eur J Immunol 39(11):3066-77
  Rausch S, Huehn J, Loddenkemper C, Hepworth M.R., Klotz C, Sparwasser T, Hamann A, Lucius R, Hartmann S
  
• (2009) Gastrointestinal nematode infection interferes with experimental allergic airway inflammation but not atopic dermatitis. Clin Exp Allergy 39(10):1585-1596
  Hartmann S, Schnoeller C, Dahten A, Avagyan A, Rausch S, Lendner M, Bocian C, Pillai S, Loddenkemper C, Lucius R, Worm M, Hamelmann E
  
• (2009) Generation of HCMV-specific T-cell lines from seropositive solid-organ-transplant recipients for adoptive T-cell therapy. J Immunother 32(9):932-940
  Brestrich G, Zwinger S, Roemhild A, Noutsias M, Rohde M, Keeren K, Sawitzki B, Volk HD, Reinke P, Hammer MH
  
• (2009) Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis. Proc Natl Acad Sci USA 106(31):12998-3003
  Blume M, Rodriguez-Contreras D, Landfear S, Fleige T, Soldati-Favre D, Lucius R, Gupta N
  
• (2009) Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080
  Bergthaler A, Flatz L, Verschoor A, Hegazy AN, Holdener M, Fink K, Eschli B, Merkler D, Sommerstein R, Horvath E, Fernandez M, Fitsche A, Senn BM, Verbeek JS, Odermatt B, Siegrist CA, Pinschewer DD
  
• (2009) Intestine and environment of the chicken as reservoirs for extraintestinal pathogenic Escherichia coli strains with zoonotic potential. Appl Environ Microbiol. 75(1):184-192
  Ewers C, Antão EM, Diehl I, Philipp HC, Wieler LH
  
• (2009) Lipid Modifications of Ras Sense the Membrane Environment and Induce Local Enrichment. Angew Chem Int Ed 48:8784-8787
  Vogel, A., Reuther, G., Weise, K., Triola, G., Nikolaus, J., Tan, K.-T., Nowak, C., Herrmann, A., Waldmann, H., Winter, R., Huster, D.
  
• (2009) Massive encapsulation of larval Anguillicoloides crassus in the intestinal wall of Japanese eels. Parasites & Vectors 2:48
  Heitlinger EG, Laetsch DR, Weclawski U, Han YS, Taraschewski H
  
• (2009) Molecular rods with oligospiroketal backbone as anchors in biological membranes. Angew Chem Int Ed 48:4433-4435
  Müller P., Nikolaus J., Schiller S., Herrmann A., Möllnitz K., Czapla S., Wessig P.
  
• (2009) Negative correlation between individual and colony level virulence of Paenibacillus larvae, the etiological agent of American foulbrood of honeybees; Appl Environ Microbiol 75(10):3344-3347
  Sandra Rauch, Ainura Ashiralieva, Kati Hedtke, and Elke Genersch
  
• (2009) Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity 30(5):721-730
  Tokoyoda K, Zehentmeier S, Hegazy AN, Albrecht I, Grün JR, Löhning M, Radbruch A
  
• (2009) Signature-tagged mutagenesis in a chicken infection model leads to the identification of a novel avian pathogenic Escherichia coli fimbrial adhesin. PLoS One. 4(11):e7796
  Antão EM, Ewers C, Gürlebeck D, Preisinger R, Homeier T, Li G, Wieler LH
  
• (2009) Use of suppression subtractive hybridization to identify genetic differences between differentially virulent genotypes of Paenibacillus larvae, the etiological agent of American Foulbrood of honeybees; Environ Microbiol Rep 1(4):240-250
  Anne Fünfhaus, Ainura Ashiralieva, Rainer Borriss and Elke Genersch
  
• 2009 Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation. Epigenetics 4(8): 577-86
  Fassi Fehri L, Rechner C, Janβen S, Mak TN, Holland C, Bartfeld S, Brüggemann H, Meyer TF
  
• Lateral distribution of the transmembrane domain of influenza virus hemagglutinin revealed by time-resolved fluorescence imaging. J Biol Chem. 2009 Jun 5;284(23):15708-16
  Scolari S, Engel S, Krebs N, Plazzo AP, De Almeida RF, Prieto M, Veit M, Herrmann A
  
• (2010) A matter of timing: early, not chronic phase intestinal nematode infection restrains control of a concurrent enteric protozoan infection. Eur J Immunol 40(10):2804-2815
  Rausch S, Held J, Stange J, Lendner M, Hepworth MR, Klotz C, Lucius R, Pogonka T, Hartmann S
  
• (2010) A matter of timing: early, not chronic phase intestinal nematode infection restrains control of a concurrent enteric protozoan infection. Eur J Immunol 40(10):2804-2815
  Rausch S, Held J, Stange J, Lendner M, Hepworth MR, Klotz C, Lucius R, Pogonka T, Hartmann S
  
• (2010) Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. Nat Med 16(3):339-345
  Flatz L, Hegazy AN, Bergthaler A, Verschoor A, Claus C, Fernandez M, Gattinoni L, Johnson S, Kreppel F, Kochanek S, Broek Mv, Radbruch A, Lévy F, Lambert PH, Siegrist CA, Restifo NP, Löhning M, Ochsenbein AF, Nabel GJ, Pinschewer DD
  
• (2010) Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gamma RIIB-deficient mice. J Exp Med 207(12):2767-2778
  Tiller T, Kofer J, Kreschel C, Busse CE, Riebel S, Wickert S, Oden F, Mertes MM, Ehlers M, Wardemann H
  
• (2010) Direct visualization of large and protein-free hemifusion diaphragms. Biophys J 98:1192-1199
  Nikolaus J., Stöckl M., Langosch D., Volkmer R., Herrmann, A.
  
• (2010) Disruption of the lipid-transporting LdMT- LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion. PLoS One 5(8):e12443
  Weingärtner A, Drobot B, Herrmann A, Sánchez-Cañete MP, Gamarro F, Castanys S, Günther Pomorski T
  
• (2010) Fatal canine distemper infection in a pack of African wild dogs in the Serengeti ecosystem, Tanzania. Vet Microbiol 146(3-4):245-252
  Goller KV, Fyumagwa RD, Nikolin V, East ML, Kilewo M, Speck S, Müller T, Matzke M, Wibbelt G
  
• (2010) Fatal canine distemper infection in a pack of African wild dogs in the Serengeti ecosystem, Tanzania. Veterinary Microbiology 146, 245-52
  Goller, K. V., Fyumagwa, R. D., Nikolin, V., East, M. L., Kilewo, M., Speck, S., Müller, T., Matzke, M. & Wibbelt, G.
  
• (2010) Genetic reassortment between high-virulent and low-virulent Dobrava- Belgrade virus strains. Virus Genes 41(3):319-328
  Kirsanovs S, Klempa B, Franke R, Lee MH, Schönrich G, Rang A, Kruger DH
  
• (2010) Genetic reassortment between high-virulent and low-virulent Dobrava- Belgrade virus strains. Virus Genes 41(3):319-328
  Kirsanovs S, Klempa B, Franke R, Lee MH, Schönrich G, Rang A, Kruger DH
  
• (2010) Hemagglutinin of influenza virus partitions into the nonraft domain of model membranes. Biophys J 99:489-498
  Nikolaus, J., Scolari, S., Bayraktarov, E., Jungnick, N., Engel, S., Plazzo, A.P., Stöckl, M., Volkmer, R., Veit, M., Herrmann, A.
  
• (2010) In-vitroinduced Th17 cells fail to induce inflammation in vivo and show an impaired migration into inflamed sites. Eur J Immunol 40(4):1089-1098
  Janke M, Peine M, Nass A, Morawietz L, Hamann A, Scheffold A
  
• (2010) Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32(1):116-128
  Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M
  
• (2010) Looking into the future of Trichuris suis therapy. J Allergy Clin Immunol. 125(3):767-768
  Hepworth M.R., Hamelmann E, Lucius R, Hartmann S
  
• (2010) Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion. Cell Microbiol 12(8):1134-1143
  Eilers B, Mayer-Scholl A, Walker T, Tang C, Weinrauch Y, Zychlinsky A
  
• (2010) Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature 467(7315):591-595
  Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC
  
• (2010) Switch to high-level virus replication and HLA class I upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. Virology 405(1):70-80
  Lütteke N, Raftery MJ, Lalwani P, Lee MH, Giese T, Voigt S, Bannert N, Schulze H, Krüger DH, Schönrich G
  
• (2010) Switch to high-level virus replication and HLA class I upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. Virology 405(1):70-80
  Lütteke N, Raftery MJ, Lalwani P, Lee MH, Giese T, Voigt S, Bannert N, Schulze H, Krüger DH, Schönrich G
  
• (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J Cell Biol 190(1):143-57
  Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF
  
• (2010) The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 11(11):1057-1062
  Stittrich AB, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N, Radbruch A, Mashreghi MF
  
• (2010) The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 11(11):1057-1062
  Stittrich AB, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N, Radbruch A, Mashreghi MF
  
• (2010) Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proc Natl Acad Sci U S A 107(50):21641-21646
  Bergthaler A, Flatz L, Hegazy AN, Johnson S, Horvath E, Löhning M, Pinschewer DD
  
• (2010). Visualization of lipid domain specific protein sorting in giant unilamellar vesicles. Liposomes: Methods and protocols: Vol. 2: Biological Membrane Models. Ed. V. Weissig, Humana Press, Springer New York, London. pp.115-126
  Stöckl M., Nikolaus J., Herrmann A.
  
• 2010 Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants. Journal of Microbiological Methods. 83 (2): 211-6
  Sörensen M, Mak TN, Hurwitz R, Ogilvie LA, Mollenkopf HJ, Meyer TF, Brüggemann H
  
• 2010 Proteomic identification of secreted proteins of Propionibacterium acnes. BMC Microbiology. 10:230
  Holland C, Mak TN, Zimny-Arndt U, Schmid M, Meyer TF, Jungblut PR, Brüggemann H
  
• AiC1qDC-1, a novel gC1q-domain-containing protein from bay scallop Argopecten irradians with fungi agglutinating activity. Dev Comp Immunol. 2010 Aug;34(8):837-46
  Kong P, Zhang H, Wang L, Zhou Z, Yang J, Zhang Y, Qiu L, Wang L, Song L
  
• FLIM-FRET and FRAP reveal association of influenza virus haemagglutinin with membrane rafts. Biochem J. 2010 Jan 15;425(3):567-73
  Engel S, Scolari S, Thaa B, Krebs N, Korte T, Herrmann A, Veit M
  
• Hemagglutinin of influenza virus partitions into the nonraft domain of model membranes. Biophys J. 2010 Jul 21;99(2):489-98
  Nikolaus J, Scolari S, Bayraktarov E, Jungnick N, Engel S, Pia Plazzo A,Stöckl M, Volkmer R, Veit M, Herrmann A
  
• Interaction of mammalian seminal plasma protein PDC-109 with cholesterol: implications for a putative CRAC domain. Biochemistry. 2010 Oct 26;49(42):9027-31
  Scolari S, Müller K, Bittman R, Herrmann A, Müller P
  
• Lipid domain specific recruitment of lipophilic nucleic acids: a key for switchable functionalization of membranes. J Am Chem Soc. 2010 Nov 17;132(45):16066-72
  Loew M, Springer R, Scolari S, Altenbrunn F, Seitz O, Liebscher J, Huster D, Herrmann A, Arbuzova A
  
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