Project Details
Projekt
"FAVORS - early warning system for anastomosis failure through organic absorbable sensor technology" in visceral surgery
Subject Area
General and Visceral Surgery
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 461264398
Anastomotic leakage is one of the most severe problems in visceral surgery, causing a significant increase in morbidity and mortality. There is a lack of a specific, safe and, above all, early noninvasive diagnostics. In this project, a novel resorbable sensor film is to be developed, which is integrated into the anastomosis and thus providing on-site data for the early detection of anastomotic leakage. For this purpose, the applicants can build on large experience with management of anastomotic leakages - especially with regard to metabolic healing processes and the special complication management in anastomotic leaks - and with the design and production of highly specialized thin-film electronic components and sensors on flexible substrates. The planned project will initially develop a resorbable film that is placed directly between the anastomosis partners and subsequently tested in animal experiments in pigs. In a second step, new sensors will be mounted on this film to allow measurements directly on the pig's anastomosis. This requires the establishment of readings which are then re-tested in pigs with experimental anastomotic leakage and without anastomotic leak, to represent a deviation from the normal course of healing and thus early to detect anastomotic leakage. The development and establishment of a novel resorbable sensor film opens up the possibility of detecting anastomotic leaks earlier and thus significantly reducing the morbidity and mortality of patients after major surgery in visceral surgery.
DFG Programme
Research Grants
