Molecular regulation of differentiation and cell cycle in tumor-repopulating melanoma cells (A11)

• Subject Area: Dermatology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424228829

Roesch has shown that the histone demethylase JARID1B triggers transitions between rapid and slow-cycling cell states that underlie melanoma cell plasticity and therapy resistance. Roesch aims to reveal the molecular mechanisms by analysing and targeting critical interac-tions with e.g. retinoblastoma protein for functional separation. He will also develop chemical approaches for acute perturbation of JARID1B and its partners followed by real-time monitor-ing of cellular responses. This project will lead into developing potential combination therapies of the JARID1B-dependent drug resistant cell state using in vitro and in vivo models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1430: Molecular Mechanisms of Cell State Transitions
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Alexander Roesch