VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control (A03)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424228829

Meyer will concentrate on deconvolving the functions of the VCP/p97 ATPase and its many cofactors proteins in DNA damage responses. He will use a systematic combination of mass spectrometry, PROTAC-induced protein degradation and cell-free reconstitution approaches. The aim is to identify targets and dissect the exact role of p97-cofactor complexes and its dis-tinct components in alternative DNA damage repair pathways, and then explore the relevance for genomic stability and survival in cancer cell models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1430: Molecular Mechanisms of Cell State Transitions
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Hemmo Meyer