Major depression as a transient functional lesion model of motor control (C06)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology ; Biological Psychiatry
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431549029

This project aims at (i) scrutinising the neural substrates of motor control when these are affected by internal states, and (ii) exploring how primary sympathetic effectors affect motor control circuits. Task-based fMRI analyses of effective connectivity in humans will be employed to generate model-based computational indices of neural network function of motor control and reward processing. These models are then used to test for individual expressions of motor function and their modulation by standardised pro-dopaminergic treatment as well as inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1451: Key mechanisms of motor control in health and disease
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Frank Jessen; Professor Dr. Marc Tittgemeyer