Striatal dopamine and volitional motor control: vigour, planning, and incentive salience (C03)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431549029

Effects of progressive dopamine deficiency on networks engaged in vigorous volitional movements as encountered in compensated (prodromal) to decompensated (clinical stage) Parkinson’s disease will be explored. Structural and functional networks implicated in the planning and incentive salience of vigorous volitional movements will be investigated using a combination of computational phenotyping and molecular, functional, and structural neuroimaging technologies. The project will also probe dynamic network states, network topologies, and their efficacy associated with mitigation of motor deficits.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1451: Key mechanisms of motor control in health and disease
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Thilo van Eimeren; Merle Hönig, Ph.D.