Optimal transport based colocalization (C06)

• Subject Area: Cell Biology ; Mathematics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432680300

Biological cells are highly organized complex entities. For instance, it is hypothesized that cells regulate metabolic activity by controlling the dynamic assembly of the involved proteins. This concept is called substrate channeling and perturbations thereof are associated with various diseases. Past and ongoing developments in super-resolution microscopy techniques allow increasingly detailed images of cells and protein distributions far below the conventional diffraction limit. In this project we seek to develop tools based on optimal transport theory for the analysis of the acquired images to understand to what extent cells can control the relative spatial distribution of proteins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1456: Mathematics of Experiment: The challenge of indirect measurements in the natural sciences
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Stefan Jakobs; Professor Dr. Axel Munk; Professor Dr. Bernhard Schmitzer