Statistical methods for reconstruction of continuous movements from cryo-EM data (A05)

• Subject Area: Mathematics ; Structural Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432680300

Cryo-electron microscopy (EM) does not only determine biomolecular structures at high resolution, but shows also potential for unraveling the entire spectrum of conformational dynamics of macromolecular assemblies. Our project aims to develop new computational approaches to reconstruct deformable 3D models that capture all of the structural dynamics hidden in cryo-EM projection images. The additional information about the dynamics of proteins will lead to a deeper understanding of enzymatic mechanisms and provide new insights into medically relevant modes of inhibiting proteins by drugs and binders.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1456: Mathematics of Experiment: The challenge of indirect measurements in the natural sciences
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Michael Habeck; Professor Dr. Holger Stark