Flow nuclear magnetic resonance spectrometer

• Subject Area: Molecular Chemistry
• Term: Funded in 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 456121295

Resource-economic and sustainable synthetic strategies are of key importance for modern organic chemistry. Especially the activation of C–H and C–C bonds offers a powerful tool for the efficient assembly of structural complex molecules. The development of novel, biologically active, in particular anti-viral compounds via C–H activation, require fast optimization methods and easily scalable reaction conditions. Direct in-operando reaction monitoring has the power to accelerate this process significantly. Hence, it is essential for the research groups of the Institute for Organic and Biomolecular Chemistry to have access to a high-resolution flow-NMR-spectrometer. The envisioned projects i) electrochemical C–H activation in flow, ii) photo-flow reactions, iii) late-stage functionalization of peptides, iv) synthesis of bioactive molecules in flow, and v) development of a substrate library for studies with COVID 19 require a fast optimization and an in-depth mechanistic understanding to establish ideal reaction conditions. Unfortunately, thus far a high-resolution flow-NMR-spectrometer is not available at the Georg-August-Universität Göttingen. This instrument allows for the exact investigations of reactions as to the formation of the target and coupling products, as well as the reaction kinetics and nature of key intermediates. The excellent resolution of a high-resolution spectrometer enables meticulous kinetic studies of challenging reactions and thus valid insights for the optimization and understanding of catalytic transformations.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Durchfluss-NMR-Spektrometer (300 MHz)
• Instrumentation Group: 1740 Hochauflösende NMR-Spektrometer
• Applicant Institution: Georg-August-Universität Göttingen
• Leader: Professor Dr. Lutz Ackermann