Project Details
Projekt
The roles of VGCCs and Ca2+ pumps in orchestrating SV release, recycling, and presynaptic homeostatic plasticity (B12*)
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 221828878
The new project B12N will investigate the molecular mechanisms modulating activity-dependent and homeostatic regulation of synaptic vesicle (SV) recycling at the presynapse. We previously identified the differential modulation of SV recycling by the calcium channels Cav1 and Cav2 due to their different synaptic localizations. We will now assess their respective contribution to synaptic calcium influx, as well as the interaction between Cav1 and the intracellular calcium stores in the endoplasmic reticulum, and how this influences SV recycling modes. We will also characterize their role in controlling presynaptic homeostatic plasticity in Drosophila neuromuscular junctions and in the mammalian hippocampus.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Heads
Professor Dr. Carsten Duch; Professor Dr. Martin Heine
