Adaptive cell-matrix nanosystems (B05)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation ; Biophysics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 433682494

This interdisciplinary project aims at the generation of a biosynthetic material, in which mammalian cells are utilized as information-processing elements that sense, integrate, and feedback on physiological stimuli. Using the expertise of three laboratories specialized in cell biology/biophysics, biomaterial science, and coordination chemistry, 3D hydrogels harbouring mesenchymal stem cells and novel metal-organic based tension sensors, will be generated. The resulting hybrid nanosystem should sense and adapt to various stimuli including mechanical forces, biochemical signals, and light.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1459: Intelligent matter: From responsive to adaptive nanosystems
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Carsten Grashoff; Professor Dr. Cristian Alejandro Strassert; Dr. Britta Trappmann