Regulation of CNS Lupus by brain macrophages (B18*)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

CNS Lupus is a clinical entity that includes conditions as diverse as cognitive dysfunction andpsychosis. Diagnosing CNS lupus is challenging and treatment options are limited. Despite theseunmet clinical needs, our knowledge of its pathogenesis is scarce. Here, we aim to shed light to therole of type I interferons, microglia and CNS- associated macrophages in the pathogenesis of CNSlupus at single cell resolution. Our goal is to uncover basic pathogenetic principles underlying thespectrum of clinical presentations of neuropsychiatric lupus and thus identify new diagnostic tools andtreatment targets.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Antigoni Triantafyllopoulou