Adrenergic regulation of myeloid cells in chronic inflammation and neurodegeneration (B17*)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Neuronal regulation of immune cell function is emerging as a critical regulator of chronic inflammationand neurodegeneration. In this context, the β2-adrenergic receptor (Adrb2) on myeloid cells waslinked to the pathogenesis of chronic inflammatory diseases. We propose to systematically investigateimmune regulation by Adrb2 using conditional deletion of Adrb2 in neutrophils, macrophages, anddendritic cells. These conditional knockout mice will be combined with disease models, nextgenerationsequencing and the modulation of neuronal activation to dissect the molecular pathwaysthat regulate chronic inflammation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Dr. Christoph Siegfried Niki Klose