Deciphering molecular recruitment mechanisms of microglial progenitors during development (A09*)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Yolk sac derived microglial progenitors colonize the central nervous system (CNS) early duringembryonic development. Dysfunctional microglial development was linked with several CNSpathologies. However the exact recruitment signals for embryonic microglia are still poorly understood.Therefore, we aim to identify the molecular recruitment mechanisms of microglial progenitors viaunbiased approaches. We will further analyse the role of integrins during microglial colonization andelucidate the tissue specificity of the identified signals. The proposed project will allow to understandthe molecular machinery used by microglial progenitors to efficiently colonize the CNS.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Katrin Kierdorf