Nanocapsule-based functional analysis of myeloid cells and platelets in autoimmune diseases (C06)

• Subject Area: Dermatology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

A hallmark of cutaneous autoimmune diseases is the infiltration of myeloid cells into the skin and affected organs. However, the role of subpopulations of myeloid cells, in particular of inflammatory and patrolling monocytes, and their crosstalk with platelets remains largely unknown in the pathogenesis of systemic Lupus erythematosus (SLE) and systemic sclerosis (SSc). We will combine novel nanocapsule-based approaches with multiscale imaging techniques in mouse models of SSc and SLE to decipher molecular mechanisms of myeloid cell and platelet function, their interaction and the role of ROS-mediated processes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Professorin Dr. Katharina Landfester; Professorin Dr. Kerstin Steinbrink