Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum (C04+)

• Subject Area: Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

To define routes and mechanisms of leukocyte infiltration into the peritoneum during peritonitis a multiscale imaging approach will be employed to analyse the temporo-spatial dynamics of the extravasation of different myeloid populations across the high endothelial venule (HEV)-like versus conventional postcapillary venules of the omentum in response to different sterile or infectious stimuli. Combined with single cell RNA sequencing of omental vessels, this will identify marker molecules for the development of non-invasive imaging strategies for assessing acute peritoneal inflammation and, potentially, also for its manipulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Head: Professorin Dr. Lydia Sorokin