Imaging of inflammatory and regulatory mechanisms in arthritis (C03)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology ; Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

Immune-regulatory mechanisms limiting immunological responses are promising new therapeutic targets for chronic inflammatory diseases. This project will investigate to what extent S100A8/A9 reprograms myeloid cells in a negative feedback loop to a regulatory phenotype, in particular immunosuppressive MDSCs, to dampen down the immune response in arthritis. Multiscale imaging methods will be used to localize and study the interaction of MDSCs, S100A8/A9 and activated leukocytes in mouse models of acute and chronic arthritis over time and to evaluate the therapeutic potential of induced MDSCs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Dr. Sven Hermann; Professor Dr. Thomas Vogl, Ph.D.