Project Details
Projekt
Dynamic PET-MRI for integrated quantification of molecular immune responses and their vascular consequences (B06)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
The aim of the project is to elaborate synergistic links across PET/MRI by dual dynamic recordings and pharmacokinetic modelling. A framework to deduce the PET arterial input function from MRI will be established by performing simultaneous recordings in animals, and finally tested in patient scans. Building on this, approaches will be evaluated to integrate MRI-derived information on perfusion and permeability into PET modelling in mouse models of ischemia driven inflammation in the heart and kidney to uncover and better understand unspecific radiotracer uptake phenomena.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Dr. Philipp Backhaus; Privatdozent Dr. Florian Büther
