Project Details
Projekt
Quantitative MRI of organ-specific vascular permeability and immune cell dynamics by combination with mass spectrometric imaging (B02)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
The aim of this project is to develop combined in vivo MRI and ex vivo mass spectrometry imaging (MSI) methods including both, laser ablation-inductively coupled plasma-mass spectrometry imaging (LA-ICP-MSI) and matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI). MSI shall be used to develop fully quantitative MRI methods as part of our comprehensive multiscale imaging strategy to analyse immune responses in disease models and patients in vivo. The overarching question is how quantitative MR parameters depend on elemental and molecular patterns in tissues, and how this dependence evolves during inflammatory responses.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professor Dr. Cornelius Faber; Professor Dr. Uwe Karst
