Project Details
Projekt
Targeting immune cell dynamics by longitudinal whole-body imaging and mathematical modelling (A05)
Subject Area
Medical Physics, Biomedical Technology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
We develop strategies for tracking and quantifying (immune) cell populations or even single cells in long-term (days) whole-body PET studies in mice and humans. This will be achieved through novel acquisition protocols, measured and simulated phantom data, use of prior information from MRI and microscopy, mathematical modelling, and mathematical analysis of image reconstruction with novel regularization paradigms based on optimal transport. Particular applications include imaging and tracking of macrophages and neutrophils following myocardial ischemia-reperfusion or in arthritis and sepsis.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professor Dr. Klaus Schäfers; Professor Dr. Benedikt Wirth
