Targeting of S100A8/A9 for imaging of inflammatory disorders (A03)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

Activated monocytes and granulocytes are key to inflammatory diseases and release the alarmin S100A8/A9 in high concentrations, triggering sterile as well as infectious inflammatory processes via TLR-4. In the proposed project we will establish a specific S100A8/A9 tracer combining X-ray structure analysis and chemical synthesis. The tracer core will be linked to different labels suited for PET, SPECT, fluorescent or photoacoustic imaging techniques. In summary, we will create a new toolset to monitor the onset of inflammatory responses, the spatio-temporal location and resolution of inflammation in the context of the whole organism.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Dr. Andreas Faust; Privatdozent Dr. Günter Fritz