A functional genomics approach to understand inflammation in obesity (P19)

• Subject Area: Immunology ; Epidemiology and Medical Biometry/Statistics ; Medical Informatics and Medical Bioinformatics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Chronic inflammation in obese individuals plays a central role in the pathogenesis of cardiovascular diseases (CVD). This project aims to delineate the factors that influence inflammatory and metabolic complications in individuals with obesity: 1) to understand whether CVD complications are determined by the immune characteristics of the individual; 2) describe the (epi)genetic factors that influence inflammation, and 3) investigate the metabolic pathways related to inflammation. To achieve these aims, we will perform a system biology approach that integrates immune parameters with genomic, transcriptomic, and metabolomic data in a cohort of 300 individuals with obesity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Mihai G. Netea; Katarzyna Placek, Ph.D.