The role of cyclic nucleotides in the regulation of adipose tissue resident myeloid cells (P17)

• Subject Area: Immunology ; Endocrinology, Diabetology, Metabolism ; Nutritional Sciences ; Pharmacology
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

This project aims to investigate the role of cyclic GMP (cGMP) signalling in myeloid cells during metaflammation. Although myeloid cells play an outstanding role in adipose tissue (AT) inflammation, not much is known about the signalling pathways involved. Our previous work shows that cGMP signaling is negatively affected in adipose tissue during obesity. In this project, we will identify the cGMP signalling components in AT-resident macrophages and the effect of cGMP on macrophage function during metaflammation. Furthermore, we will analyse cGMP signalling in vivo and in human macrophages during obesity and metaflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Alexander Pfeifer